Regularity Theory and Superalgebraic Solvers for Wire Antenna Problems

We consider the problem of evaluating the current distribution $J(z)$ that is induced on a straight wire antenna by a time-harmonic incident electromagnetic field. The scope of this paper is twofold. One of its main contributions is a regularity proof for a straight wire occupying the interval $[-1,1]$. In particular, for a smooth time-harmonic incident field this theorem implies that $J(z) = I(z)/\sqrt{1-z^2}$, where $I(z)$ is an infinitely differentiable function—the previous state of the art in this regard placed $I$ in the Sobolev space $W^{1,p}$, $p>1$. The second focus of this work is on numerics: we present three superalgebraically convergent algorithms for the solution of wire problems, two based on Hallén's integral equation and one based on the Pocklington integrodifferential equation. Both our proof and our algorithms are based on two main elements: (1) a new decomposition of the kernel of the form $G(z) = F_1(z) \ln\! |z| + F_2(z)$, where $F_1(z)$ and $F_2(z)$ are analytic functions on the real line; and (2) removal of the end-point square root singularities by means of a coordinate transformation. The Hallén- and Pocklington-based algorithms we propose converge superalgebraically: faster than $\mathcal{O}(N^{-m})$ and $\mathcal{O}(M^{-m})$ for any positive integer $m$, where $N$ and $M$ are the numbers of unknowns and the number of integration points required for construction of the discretized operator, respectively. In previous studies, at most the leading-order contribution to the logarithmic singular term was extracted from the kernel and treated analytically, the higher-order singular derivatives were left untreated, and the resulting integration methods for the kernel exhibit $\mathcal{O}(M^{-3})$ convergence at best. A rather comprehensive set of tests we consider shows that, in many cases, to achieve a given accuracy, the numbers $N$ of unknowns required by our codes are up to a factor of five times smaller than those required by the best solvers previously available; the required number $M$ of integration points, in turn, can be several orders of magnitude smaller than those required in previous methods. In particular, four-digit solutions were found in computational times of the order of four seconds and, in most cases, of the order of a fraction of a second on a contemporary personal computer; much higher accuracies result in very small additional computing times

Preliminary psychometric data for a Portuguese scale to assess history of depressive symptomatology with a college student sample

We developed a Portuguese questionnaire that could assess history of depressive symptoms. The Depressive History Questionnaire was based on the Depressive Experience Subscale from the Thalbourne Manic-Depressiveness Scale, which was translated into Portuguese. The Depressive History Questionnaire was administered to 459 college students. Female students scored significantly higher than male students. Cronbach alpha was .64 and was considered satisfactory. Principal component analysis revealed that the questionnaire measures only one dimension. Confirmatory factor analysis provided support for the fit of the one-factor model The Depressive History Questionnaire correlates positively and significantly with the Portuguese versions of both the Beck Depression Inventory - II and of the Depressive Personality Disorder Inventory. (Campos et al., 2009 - [email protected]

Copyright Law in the Digital Age

Copyright infringement of digital media is an ever-increasing problem. While there have been attempts to solve this problem through both legal and technological measures, no solutions have been satisfactory. Many people are uneducated about the legal aspects, and technological measures are easily circumvented. By analyzing various documents and news articles, and by conducting interviews with various people representing all sides of the issue, the team was able assess the situation and to provide recommendations to improve it

The influence of dietary fatty acid and fasting on the hepatic lipid metabolism of barramundi (Lates calcarifer)

For many fish species, dietary fish oil (FO) has been substituted with other oils such as poultry oil (PO) without affecting growth performance. However, in barramundi, the mechanisms by which fatty acid metabolism is regulated are poorly understood, and the effects of FO substitution are unknown. This study defined changes in the expression of genes controlling the metabolism of fatty acids in barramundi over a 24-h time period after a single meal. From one to 12h after a single feeding event, the expression of fatty acid synthesis genes in the liver was upregulated, while genes involved in the β-oxidation showed minimal alteration. However, the expression of β-oxidation genes was significantly correlated with the expression of genes regulating fatty acid synthesis. In a second experiment, the changes in liver fatty acid composition and gene expression were defined after FO was substituted with PO. Liver fatty acid profile reflected the diet composition, with some subtle exceptions supporting the enrichment of certain long-chain polyunsaturated fatty acids in the liver. The fish from all experimental groups preferentially retained more docosahexaenoic acid than eicosapentaenoic acid in the liver, suggesting a bioconversion of this fatty acid to intermediate fatty acids. Replacement of FO with PO significantly regulated genes controlling both fatty acid synthesis and catabolism pathways, potentially related to a higher percentage of monounsaturated fatty acids, in the livers of fish fed these diets. The results demonstrated that diet composition significantly altered the lipid metabolism in barramundi and that there was a balance between direct dietary effects and endogenous synthetic capacity

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a

The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevis rapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a complex with EtCRK2. Using the non-radioactive time-resolved fluorescence energy transfer (TR-FRET) assay, we demonstrated the ability of EtCYC3a to activate EtCRK2 as shown previously for XlRINGO. The EtCRK2/EtCYC3a complex was used for a combined in vitro and in silico high-throughput screening approach, which resulted in three lead structures, a naphthoquinone, an 8-hydroxyquinoline and a 2-pyrimidinyl-aminopiperidine-propane-2-ol. This constitutes a promising starting point for the subsequent lead optimization phase and the development of novel anticoccidial drugs

Efficient high-order evaluation of scattering by periodic surfaces: deep gratings, high frequencies, and glancing incidences

We present a superalgebraically convergent integral equation algorithm for evaluation of TE and TM electromagnetic scattering by smooth perfectly conducting periodic surfaces z=f(x). For grating-diffraction problems in the resonance regime (heights and periods up to a few wavelengths) the proposed algorithm produces solutions with full double-precision accuracy in single-processor computing times of the order of a few seconds. The algorithm can also produce, in reasonable computing times, highly accurate solutions for very challenging problems, such as (a) a problem of diffraction by a grating for which the peak-to-trough distance equals 40 times its period that, in turn, equals 20 times the wavelength; and (b) a high-frequency problem with very small incidence, up to 0.01° from glancing. The algorithm is based on the concurrent use of Floquet and Chebyshev expansions together with certain integration weights that are computed accurately by means of an asymptotic expansion as the number of integration points tends to infinity

Short-term movements and habitat preferences of sailfish, Istiophorus platypterus (Istiophoridae), along the southeast coast of Brazil

Pop-up satellite archival tags (PSATs) were deployed on four sailfish, Istiophorus platypterus, in the coastal waters of Rio de Janeiro State in southeast Brazil during January and February of 2009 (sailfish I and II) and between November 2010 and January 2011 (sailfish III and IV). The total number of days monitored (i.e., time that the tags remained attached) were 12 (sailfish I), 51 (sailfish II), 16 (sailfish III) and 43 days (sailfish IV). The results indicate a clear pattern of vertical habitat utilization with the majority of the time spent concentrated near the uniform sea surface layer occupying a relatively narrow temperature range. Despite the clear preference for epipelagic surface waters, sailfish regularly undertook vertical excursions into deeper waters (>50 m) within three to six hour intervals. Most Probable Tracks (estimated from raw geolocations using the state-space Kalman filter model) and linear displacements suggested that tagged sailfish did not move significant distances from the tagging site. In brief, our report provides information regarding the biology of sailfish in the southwestern Atlantic and how vertical distributions during the day and night are influenced by water temperature and how this information can improve sailfish stock assessments in southwestern Atlantic Ocean.Quatro exemplares de agulhão-vela foram marcados com marcas eletrônicas monitoradas por satélite ('Pop-up satellite archival tags - PSATs') nas águas costeiras do Rio de Janeiro, sudeste do Brasil, durante janeiro e fevereiro de 2009 (agulhão-vela I e II) e entre novembro de 2010 e janeiro de 2011 (agulhão-vela III e IV). O número total de dias monitorados (ou seja, o tempo que as marcas permaneceram implantadas nos peixes) foram 12 (agulhão-vela I), 51 (agulhão-vela II), 16 (agulhão-vela III) e 43 dias (agulhão-vela IV). Os resultados demonstram um padrão claro de utilização do hábitat com a maior parte do tempo despendido predominantemente próximo à superfície do mar ocupando águas com uma faixa de temperatura restrita. Apesar da preferência por águas superficiais, os agulhões frequentemente realizaram mergulhos para águas mais profundas (ca. > 50 m) em intervalos de três a seis horas. A rota mais provável estimada a partir dos dados brutos de geolocalização e o modelo 'State-Space Kalman Filter' sugerem que os agulhões marcados não realizaram migrações significativas a partir do local de marcação. Em resumo, nossos resultados apresentam informações sobre a biologia da espécie no Atlântico Sudoeste e como as migrações verticais durante o dia e a noite são influenciadas pela temperatura da água e como essa informação pode auxiliar as avaliações de estoques de agulhão-vela no sudoeste do Atlântico.Universidade Federal de São Paulo (UNIFESP) Departamento de Ciências do MarUniversity of Florida School of Forest Resources and ConservationPelagic Research GroupInstituto de PescaUniversidade Federal Rural de Pernambuco Departamento de Pesca e AquiculturaUNIFESP, Depto. de Ciências do MarSciEL

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

BACKGROUND: Immunization of patients with Alzheimer's disease (AD) with synthetic amyloid-beta peptide (Abeta(42)) (AN1792) was previously studied in a randomized, double-blind, placebo-controlled phase 2a clinical trial, Study AN1792(QS-21)-201. Treatment was discontinued following reports of encephalitis. One year follow-up revealed that AN1792 antibody responders showed improvements in cognitive measures as assessed by the neuropsychological test battery (NTB) and a decrease in brain volume compared with placebo. METHODS: A follow-up study, Study AN1792(QS-21)-251, was conducted to assess the long-term functional, psychometric, neuroimaging, and safety outcomes of patients from the phase 2a study 4.6 years after immunization with AN1792. The results were analyzed by comparing patients originally identified as antibody responders in the AN1792 phase 2a study with placebo-treated patients. RESULTS: One hundred and fifty-nine patients/caregivers (30 placebo; 129 AN1792) participated in this follow-up study. Of the 129 AN1792-treated patients, 25 were classified in the phase 2a study as antibody responders (anti-AN1792 titers > or = 1:2,200 at any time after the first injection). Low but detectable, sustained anti-AN1792 titers were found in 17 of 19 samples obtained from patients classified as antibody responders in the phase 2a study. No detectable anti-AN1792 antibodies were found in patients not classified as antibody responders in the phase 2a study. Significantly less decline was observed on the Disability Assessment for Dementia scale among antibody responders than placebo-treated patients (p=0.015) after 4.6 years. Significant differences in favor of responders were also observed on the Dependence Scale (p=0.033). Of the small number of patients who underwent a follow-up MRI, antibody responders showed similar brain volume loss during the follow-up period subsequent to the AN1792 phase 2a study compared with placebo-treated patients. CONCLUSIONS: Approximately 4.6 years after immunization with AN1792, patients defined as responders in the phase 2a study maintained low but detectable, sustained anti-AN1792 antibody titers and demonstrated significantly reduced functional decline compared with placebo-treated patients. Brain volume loss in antibody responders was not significantly different from placebo-treated patients approximately 3.6 years from the end of the original study. No further cases of encephalitis were noted. These data support the hypothesis that Abeta immunotherapy may have long-term functional benefits

Goα Regulates Volatile Anesthetic Action in Caenorhabditis elegans

To identify genes controlling volatile anesthetic (VA) action, we have screened through existing Caenorhabditis elegans mutants and found that strains with a reduction in Go signaling are VA resistant. Loss-of-function mutants of the gene goa-1, which codes for the α-subunit of Go, have EC_(50)s for the VA isoflurane of 1.7- to 2.4-fold that of wild type. Strains overexpressing egl-10, which codes for an RGS protein negatively regulating goa-1, are also isoflurane resistant. However, sensitivity to halothane, a structurally distinct VA, is differentially affected by Go pathway mutants. The RGS overexpressing strains, a goa-1 missense mutant found to carry a novel mutation near the GTP-binding domain, and eat-16(rf) mutants, which suppress goa-1(gf) mutations, are all halothane resistant; goa-1(null) mutants have wild-type sensitivities. Double mutant strains carrying mutations in both goa-1 and unc-64, which codes for a neuronal syntaxin previously found to regulate VA sensitivity, show that the syntaxin mutant phenotypes depend in part on goa-1 expression. Pharmacological assays using the cholinesterase inhibitor aldicarb suggest that VAs and GOA-1 similarly downregulate cholinergic neurotransmitter release in C. elegans. Thus, the mechanism of action of VAs in C. elegans is regulated by Goα, and presynaptic Goα-effectors are candidate VA molecular targets